A study conducted in the United States, in some cancer types, the cause of uncontrolled tumor growth, as seen previously accepted in the scientific world is not genetic mutations in the cells revealed that low oxygen levels.
Growth of malignant tumors by the United States to improve the results of research conducted at the University of Georgia plans of treatment may lead to drastic changes were reported.
Journal of Molecular Cell Biology at the study published in the medical journal the internet, public data banks messenger RNA in the 7 different type of cancer researchers who analyzed data samples, the cells may be an important factor in long-term büyümelerindeki showed cancer in the absence of oxygen.
Low oxygen levels in cells previously made on this subject in scientific research that contribute to the development of cancer was supposed to be a factor, but it is not known to be an important factor in the growth of the cancer.
Growth model put forward as a valid proof of a new case of cancer, researchers primarily to find new methods to prevent falling oxygen levels in cells that would lead for a change, and this will result in radical treatment of cancer.
Prof. research team. Ying Xu, research is the scientific name'' hypoxia'' low oxygen levels in cells that proved an important factor in some specific types of cancer, he said.
The high cancer rates in the world that can not be explained just random genetic mutations Xu, computational biology and bioinformatics, the science of science, which brings together researchers said cancer offers opportunity to look at in a new light.
Xu,'' Cancer drugs attempt to reach the root of a specific mutation at the molecular level, but it is usually the cancer finds a new way of traveling around himself. So I think it may not be a major cause of cancer, genetic mutations,'' he said.
Researchers predicted by the model, low levels of oxygen content of the cell, the cells are normally called'' from'' Oxidative phosphorylation to intervene in the method of food into energy.
Oxygen decreases, the cells to produce energy units called'' ATP'' is a less efficient way of producing energy, and so are starting to use the method of the glycolysis of cancer cells, including more nutrients, especially glucose, are forced to work harder to get.
In the event that dangerous levels of oxygen in the process of creating new blood vessels, defined as'''' Anjiojenesis begins. Newly formed blood vessels provide fresh oxygen to the cell, and thus improving oxygen levels in the tumor cell and tumor growth by temporarily blocking.
Xu and his colleagues predicted by the model, the next stage, when cancer cells are growing more food, and this leads to decrease in the level of oxygen in the tumor grow biomass. Therefore, the energy conversion efficiency of the cells further falls in food.
This situation is becoming more open to the cancer cells, allows to take action to get more nutrients from the bloodstream, and so the vicious cycle goes on.
Why is the new growth model developed by a large number of cancer types of cancer, such as drugs, only 3 to 6 weeks emphasizing Xu explained that in a short time become resistant, the new model is of great importance to challenge Experimental cancer research said.
Study, as well as the University of Georgia, the United States medical school at Baylor College of Medicine in Houston and has contributed in China, Jilin University scientists.
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